The ties are due to be played in the week commencing December 16, which for the U’s comes after a trip to Milton Keynes Dons and before hosting Wycombe Wanderers.
Oxford United have been drawn at home to current Carabao Cup holders Manchester City in the quarter-finals of the competition.
It’s the second time in as many seasons the Premier League side have faced the U’s at the Kassam Stadium, having won 3-0 in the third round last season.
The U’s made the last eight for the first time since 1988 after defeating Sunderland on penalties, while City saw off Southampton to reach the quarter-final.
Oxford have already knocked out Premier League opposition after Karl Robinson’s side saw off West Ham United in the second round with a 4-0 victory.
The U’s have played every round at home, getting past Peterborough, Millwall, West Ham and Sunderland to reach this stage.
The ties are due to be played in the week commencing December 16, which for the U’s comes after a trip to Milton Keynes Dons and before hosting Wycombe Wanderers.