Chris Wilder will be looking for revenge over Paul Sturrocks Southend after the teams met last month in the JPT.
Southend won on penalties to go through to the area final.
Oxford will see if Liam Davis, Lewis Montrose, Michael Duberry and Peter Leven are fit for the match. New keeper Luke McCormick will be in the squad.
Southend United team last match:01 Smith,02 Clohessy,04 Spillane,06 Cresswell,15 Phillips,18 Leonard,23 Barker,08 Timlin,14 Hurst,10 Corr,21 Tomlin Booked
Substitutes:17 Bentley,03 Straker,16 Prosser,19 Spicer,30 Woodyard,09 Harris,32 Njie
The 12 goal striker comes back into the squad after being out since 1st Jan with an ankle injury.
Oxford United 442:31 Crocombe,02 Batt,05 Duberry (Raynes – 21),06 Wright,23 O’Brien,07 Chapman,14 Rigg,20 Leven (Capaldi – 46),09 Constable,15 Potter,29 Craddock (Smalley – 80)
Substitutes:21 Brown,04 Raynes,17 Capaldi,22 Worley,08 Heslop,25 Parker,10 Smalley
10 goal striker came back with a bang last match to grab his 90th goal for the club.
Southend were formed by 1906 and are know as the Shrimpers or Seasiders.
Oxford’s record is won 19 drawn 6 lost 16 against Southend.
Southend 2 Oxford 2
Scorers Constable and Rigg
9th of Feb Home to Bristol Rovers in npower league 2 ko 15:00hrs